NSAIDs - Nonsteroidal anti-inflammatory drugs

Naproxen Side effects, Dosage, uses, Interactions and More

Side effects, dosage, Uses, Interactions, warning, precautions, pregnancy & Breast feedings effects of Naproxen.

Naproxen is NSAIDs – nonsteroidal anti-inflammatory drug which is used to relieve pain and inflammation in conditions like Osteoarthritis and Rheumatoid Arthritis.

Naproxen is Prescribed as a pain reliever medicine.Close monitoring of kidney function is necessary while consuming this drug. It is not recommended for use in patients with any bleeding disorder or a known allergy to it.


Naproxen Classification and General Details.


About Naproxen

Naproxen is a drug that reduces inflammation and pain in joints and muscles. It’s prescribed to treat diseases of joints, such as rheumatoid arthritis, osteoarthritis, and gout.

It’s also given for period pain and muscle and bone disorders, such as back pain and sprains and strains.

Naproxen is available on prescription as tablets or as a suspension. It can only be given to children when it’s prescribed for them.


Uses of Naproxen

Why it is prescribed for?

Osteoarthritis

This medicine is prescribed to treat symptoms like tender and painful joints associated with Osteoarthritis.

Rheumatoid Arthritis

This drug is given to treat symptoms like swelling, pain, and stiffness of joints associated with Rheumatoid Arthritis.

Dysmenorrhea

Naproxen is prescribed to relieve excessive pain and cramps during menstruation.

Ankylosing Spondylitis

It is used to treat symptoms like stiffness and pain associated with Ankylosing Spondylitis.

Fever and Pain

Naproxen is also used for temporary relief of minor aches and fever.

Other Conditions

  • Ankylosing spondylitis
  • Juvenile arthritis
  • Menstrual period pain
  • Tendonitis
  • Bursitis
  • Symptoms of gout

How to use Naproxen?

Read the label on packaging before taking medication.

Read the Medication Guide provided by your provider before you start taking Naproxen If your doctor has prescribed this medication.

Take this drug by mouth as directed by your doctor, usually 2 or 3 times a day with a full glass of water.

Do not lie down for at least for 10 to 15 minutes after taking this drug.

To prevent condition like stomach upset, take this medication with food, milk, or an antacid.

Take the lowest effective dose for as possible as short time with the guidance of your Doctor or Pharmacist.


Side effects / Adverse Effects

what are the Major & minor side effects for Naproxen?

Common Side Effects :

  • Headache
  • Skin rash
  • Stomach pain
  • Diarrhea
  • Gas
  • Bloating
  • Nausea and Vomiting
  • Constipation
  • Dizziness
  • Heart Burn
  • Hearing impairment
  • Change in appetite
  • Irregular menstrual periods

Serious side effects :

  • chest pain
  • shortness of breath
  • swelling of the face or throat
  • high blood pressure
  • weakness in one part or side of body
  • difficulty speaking
  • bleeding and ulcers in your stomach and intestines, with symptoms includes:
    • stomach pain
    • bloody vomit
    • blood in your stool
    • black and sticky stool
    • yellowing of  skin
    • whites of your eyes
    • unusual weight gain or swelling of arms, legs, hands, and feet
    • asthma attacks in people who already have asthma
    • low red blood cell count, which can result in fatigue, lethargy, and weakness
    • skin rash or blisters with fever

When not to use?

Contraindications of Naproxen.

Allergy

This Drug is not recommended for use in patients with a known allergy to Naproxen and other NSAID – non-steroidal anti-inflammatory drugs lile Clecoxib, Piroxicam, Aceclofenac, Ibuprofen etc.

Asthma

This medicine should not be given to patients with asthma caused by aspirin or other NSAIDs / non-steroidal anti-inflammatory drugs.

Gastrointestinal (GI) disorders

Naproxen is not recommended for use in patients with gastrointestinal bleeding disorders or active peptic ulcers.

Heart surgery

This Drug is not suitable for use in relieving pain after you have undergone a heart surgery.


What special precautions should I follow?

Before taking Naproxen :

Tell your doctor or pharmacist if you are allergic to it or other NSAIDs such as Celecoxib, Aceclofenac and ibuprofen.

Tell your doctor regarding your medical history if any such as..

  • Asthma
  • Liver Disease
  • Stomach problems
  • Heart Disease
  • High BP
  • Stroke
  • Anemia

Naproxen may cause stomach bleeding. Daily use of alcohol and tobacco combined with this medicine may increase the risk for stomach bleeding.

This medicine may make you dizzy or drowsy, Consuming it with Alcohol may make you more Dizzy.

Tell doctor if you are pregnant or if you plan to become pregnant.

This drug passes into breast milk. So avoid if you are breast feeding women.


Dosage and Administration of Naproxen.

The Dosage will depend on:

  • Age ( Child / Adult / Infant etc)
  • The condition is being treated
  • How severe your medical condition is
  • Any other medical conditions if patient have
  • How your body reacts to the primary dose

Dosage information for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis

Adult dosage (ages 18 years and older)

Naproxen:

Immediate-release oral tablet

500 to 1,000 mg daily in two divided doses with limit maximum dose of 1,500 mg per day up to limited period of 6 month.

Delayed-release oral tablet

375 to 500 mg twice daily with limit maximum dose of 1,500 mg per day up to limited period of 6 month.

Naproxen sodium:

Immediate-release oral tablet

275 to 550 mg daily in two divided doses with limit maximum dose of 1,650 mg per day up to limited period of 6 month.

Extended-release oral tablet

750 or 1,000 mg once daily with the maximum dose of 1,500 mg per day for limited time period.

Child dosage (ages 0–17 years)

A dosage guide for people younger than 18 years hasn’t been established.

Special dosage considerations

In patient older than 65 years, body process this drug very slowly hence recommended to start with lower dose.

Dosage for juvenile arthritis

Child dosage (ages 2–17 years)

Children in this age group generally prescribed the oral suspension form of this drug. The dosage will be depends on your child’s weight. It should be given twice per day in divided doses with intervals.

Child dosage (ages 0–23 months)

Dosage for children below 2 years hasn’t been established.

Dosage for tendonitis, bursitis, and menstrual pain

Adult dosage (ages 18 years and older)

Naproxen:

Immediate-release oral tablet

The initial dose is 500 mg, followed by 250 mg every 6 to 8 hours as per needed.

The max daily dose on day 1 of therapy is 1,250 mg. Additional daily doses should not be exceeding 1,000 mg.

Delayed-release oral tablet

The initial dose is 1,000 mg once a daily.

The dose can be temporarily increased to 1,500 mg once daily if greater pain relief is needed.

Naproxen sodium:

Immediate-release oral tablet

The initial dose is 550 mg, followed by 275 mg every 6 to 8 hours or 550 mg every 12 hours whatever is needed. The maximum daily dose on day 1 of is 1,375 mg. Extra daily doses should not exceed 1,100 mg.

Child dosage (ages 0–17 years)

Dosage for children younger than 18 years hasn’t been established.

Dosage for gout pain and inflammation

Adult dosage (ages 18 years and older)

Naproxen:

Immediate-release oral tablet

The initial dose is 750 mg, followed by 250 mg every 8 hours till needed.

Delayed-release oral tablet

The initial dose is 1,000 to 1,500 mg once in a day followed by 1,000 mg once daily.

Naproxen sodium:

Immediate-release oral tablet

The initial dose is 825 mg, followed by 275 mg every 8 hours till needed.

Child dosage (ages 0–17 years)

Not Recommended.

Missed Dose

The missed dose should be taken as soon as you get remember. However, the missed dose should be avoided if it is almost the time for the next dose.

Overdose

Seek emergency medical help or contact the doctor in case of overdose


Interaction of Naproxen

Drug/Food/Alcohol interactions may change “how your medications work” or “increase the risk for serious side / Adverse effects”. 

This medicine may interact differently for person to person and condition to condition.

You should ask for all the possible interactions with doctor before starting any medicine.

Interaction with Alcohol : MODERATE

Consumption of alcohol is not recommended while this medication due to an increase in the risk of stomach bleeding. Symptoms of stomach bleeding including blood in a cough or stools should be reported immediately to the doctor.

Interaction with Medicine

  • Ramipril  : MODERATE
  • Warfarin : SEVERE
  • Ketorolac : SEVERE
  • Prednisolone : MODERATE

Interaction with Other Medicines :

Antidepressant drugs : Increase the risk of Stomach bleeding 

  • citalopram
  • fluoxetine
  • fluvoxamine
  • paroxetine

Blood pressure drugs : Increase the risk on Kidney Damage

  • angiotensin-converting enzyme (ACE) inhibitors
  • angiotensin receptor blockers
  • beta-blockers, such as propranolol
  • diuretics

Heartburn drugs : Slower the effects of Naproxen

  • aluminum hydroxide
  • magnesium oxide
  • sucralfate

Nonsteroidal anti-inflammatory drugs (NSAIDs) : Increase the risk of Stomach bleeding 

  • aspirin
  • ibuprofen
  • etodolac
  • diclofenac
  • flurbiprofen
  • ketoprofen
  • ketorolac

Disease interactions

Asthma : SEVERE

Naproxen is not prescribed for use in patients with asthma caused due to aspirin or other NSAID drugs

Impaired kidney function : SEVERE

Naproxen should be used with high caution due to an increase in the risk of kidney injuries. Close monitoring of kidney function is required while receiving this medicine.

Heart Disease : MODERATE

This medicine should be given with caution in patients with heart diseases due to an increase in the risk of fluid accumulation in the body. Close monitoring of heart function and electrolytes level is highly required for such patients.

Impaired liver function : MODERATE

This drug should be prescribed with caution due to an increase in the risk of liver injury.

Food interactions 

Not reported but still it depends on person to person, so consult your doctor for more information.


Naproxen During Pregnancy

Naproxen doesn’t normally recommended in pregnancy especially if you’re 28 -30 or more weeks – unless it’s prescribed by a doctor because there might be a link between taking naproxen in pregnancy and some birth defects, in particular damage to the baby’s heart and blood vessels.

There also be a chance of miscarriage.

Discuss to your doctor about the benefits and possible harms of taking naproxen. Paracetamol is usually recommended as the first choice of painkiller or as a alternative of Naproxen for pregnant women.


Naproxen during Breast-feeding

This Medicine passes into breast milk and may have undesirable effects on a infant. Consult your doctor before taking this medicine if you are breast-feeding. Doctor may prescribed other alternative NSAID which is competitively safer.

if your baby is premature, had a low birth weight then recommended to discuss with your doctor before taking any painkillers. 


General warnings

Skin rash

This medicine may cause fatal skin allergies without any warnings. Signs and symptoms includes..

  • Rashes
  • Hives
  • Fever

Elderly population

Naproxen must be used with caution in the elderly population due to an increase in the risk of undesired side effects. Close monitoring of kidney function and symptoms of bleeding is highly required while receiving this medicine.


How Naproxen works?

Naproxen is a NSAIDs Drug (non-steroidal anti-inflammatory drug) . It works by blocking the release of certain chemical messengers that is responsible for fever, pain and inflammation (redness and swelling).


Expert Advice for Naproxen

Take this medicine with food or milk to prevent upset stomach.

Take it exactly as per the dose and duration prescribed by your doctor. prolong use may lead to serious complications such as stomach bleeding and kidney problems.

Do not take antacids like Pentoprazole, Rabeprazole etc within two hours of taking Naproxen.

Avoid consuming alcohol while taking Naproxen therapy as it can increase your risk of stomach problems.

Report your doctor if you have a history of heart disease or stroke.


Other Important Details 

Onset of action (duration of time it takes for a drug’s to come in effects)

The effect of this medicine can be observed in 30 to 60 Minutes after administration.

Duration of effect

The effect of this medicine lasts for an average 8 – 12 Hours.

Is it habit forming medicine?

No habit forming occurrence has been reported.

storage and disposal

Store it at room temperature and away from excess heat and moisture and importantly keep out of reach of children.


Commonly Asked Questions / FAQs

Does Naproxen used for pain?

Yes, Naproxen is a pain killer and is used to reduce pain. It is also used to treat diseases of joints such as rheumatoid arthritis,osteoarthritis, ankylosing spondylitis. It may even used to treat attacks of gout, muscle and bone disorders and painful periods.

Can we take Naproxen for a sinus infection?

Yes, Naproxen may be given to reduce the pain and swelling associated with sinus infection. However, It does not treat any infections

Does Naproxen medicine raise blood pressure?

Yes, It is a severe side effect. Report your doctor immediately.

Does Naproxen may cause constipation?

Yes

Does Naproxen contains sulfa substance?

No, Naproxen doesn’t contain any sulfa substance.

Is Naproxen drug addictive?

No, it has not been reported to have any addictive potential.

Does naproxen contain any caffeine?

No, Naproxen does not contain any caffeine.

Is Naproxen medicine safe?

It is safe if taken as prescribed doses for the prescribed duration as advised by doctor.

Is Naproxen a narcotic substance?

No, Naproxen is not a narcotic medicine. It is a painkiller medicine and belongs to the group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).

Is Naproxen safe during pregnancy?

No, Naproxen should not be taken during pregnancy.

Is Naproxen used as blood thinner?

No, It is a NSAID medicine.

Is Naproxen good medicine for headaches?

Naproxen may help in relieving a headache and has been prescribed for treating migraine headaches. However, it has not much effective for the relief of migraine headaches as mentioned in some studies.

Is Naproxen OTC product?

No, it is a prescription drug.

Is naproxen better than the ibuprofen?

Both are belong to the same class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs) and has a similar way of working, but their effect may vary upon individual response.

Can we take naproxen with ibuprofen?

both belong to the class of drugs known as NSAIDs. When consumed together, they can cause coagulation problems i.e increased tendency for bleeding and can also increase blood potassium levels.

Can we take naproxen with Paracetamol?

Yes, Naproxen can be taken with paracetamol. No any drug-drug interactions have been reported between the two. Please consult doctor before taking such combination.

Can we take naproxen along with meloxicam?

Both belong to the class of drugs known as NSAIDs. When consumed together, they can cause coagulation problems i.e increased tendency for bleeding and can also increase blood potassium levels.

Can I take Naproxen along with oxycodone?

Yes, Naproxen can be taken with oxycodone. No any drug-drug interactions have been reported between the two. Please consult doctor before taking the two medicines together.
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Can I take naproxen along with codeine?

Yes, Naproxen can be taken with codeine. No any drug-drug interactions have been reported between the two

Can I take Naproxen along with prednisone?

Naproxen and prednisone in combination can increase the toxicity of each other. Discuss to your doctor before taking the two medicines together.

Can I take naproxen along with tramadol?

Yes, Naproxen can be taken with tramadol. No any drug-drug interactions have been reported between the two

Can I take Naproxen for menstrual cramps (painful periods)?

Yes, Naproxen can be used for treating pain related to periods.

Can I use Naproxen for fever?

No, Naproxen is not generally used to treat fever. It is a pain-killer medicine and is used for treating various painful conditions

Can I use Naproxen for back pain?

Yes, Naproxen can be used to treat muscle and bone disorders so it can help in relieving back pain

Can we take Naproxen for a cold?

No, Naproxen is not used to treat cold.

Can I take Naproxen for a hangover condition?

No, It is not used to treat a hangover.

Can we take Naproxen for gallbladder pain?

No, It is not used to treat gallbladder pain

Can we take Naproxen for tonsillitis?

No,Naproxen is not used to treat tonsillitis

Is Naproxen used for urinary tract infection

No, It is not used to treat urinary tract infection (UTI) as it is a pain killer.

Can Naproxen used for a toothache (dental pain)?

Yes, Naproxen is a pain killer, so can be used for the treatment of a toothache (dental pain),

Does Naproxen make you sleepy / Dizzy?

Yes, Naproxen may make you feel dizzy, drowsy or tired and may cause blurred vision and you need to be careful while driving or operating any machinery.

Does Naproxen work immediately on taken?

Yes, Naproxen starts working immediately as it is absorbed quickly from the gastrointestinal tract.

Does Naproxen contains aspirin in it?

No, It does not contain aspirin.

Does Naproxen can get you high?

No, Naproxen does not get you high. It has not reported to have any addiction potential.

Can we take Naproxen for the treatment of flu?

No, It is not recommended for the treatment of flu

Can we take Naproxen for swollen glands?

Yes, It may be given to reduce the pain and swelling associated with the swollen glands but only to reduce pain not for underlying or treat real condition.
This information is to supplement, not substitute to the judgment of healthcare professionals. A healthcare professional should be consulted before taking any medicine, changing any diet or commencing or discontinuing any course of treatment.

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