NSAIDs - Nonsteroidal anti-inflammatory drugs

Celecoxib dosage, side effects, uses, Interaction, Precautions

Dosage, side effects, uses, warnings, precautions, interaction, pregnancy and breastfeeding effects of Celecoxib

Celecoxib is a NSAIDs – nonsteroidal anti-inflammatory drug . It works by reducing hormones that responsible for inflammation and pain in the body.

Celecoxib is prescribed to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

Celecoxib is given to treat juvenile rheumatoid arthritis in children who are at least 2 years old. It is also given in the treatment of hereditary polyps in the colon.


Celecoxib Classification and General Details.


Description of Celecoxib

Celecoxib is a NSAID drug specifically a COX-2 inhibitor which is prescribed to relieve pain and inflammation in conditions like..

  • Arthritis,
  • Dysmenorrhea
  • Acute Pain
  • menstrual pain
  • Inflammation

Drink adequate amount of water to minimize the stomach irritation during this medication. Close monitoring of liver function is required while receiving this medicine.


Uses of Celecoxib

Why it is prescribed for?

Osteoarthritis

Used to treat symptoms like tender and painful joints associated with Osteoarthritis.

Rheumatoid Arthritis

It used to treat symptoms like swelling, pain, and stiffness of joints associated with Rheumatoid Arthritis.

Dysmenorrhea

Celecoxib is prescribed to relieve excessive pain and cramps during menstruation.

Ankylosing Spondylitis

Celecoxib is given to treat symptoms like stiffness and pain associated with Ankylosing Spondylitis.

Acute pain

It is used to relieve pain of sprains, strains, sports injuries etc.


How to use Celecoxib?

Read the label on packaging before taking medication.

Read the Medication Guide provided by your provider before you start taking Celecoxib If your doctor has prescribed this medication.

Take this drug by mouth as directed by your doctor, usually once or twice daily with a full glass of water unless if doctor suggested other way.

To decrease the chance of stomach upset, take this drug with food or after food.


Side effects / Adverse Effects – Read in Detail >>

what are the Major & minor side effects for Celecoxib?

  • Fever
  • gas
  • Swelling of feet or lower legs
  • Increase in blood pressure
  • Diarrhe
  • sore throat
  • cold symptoms
  • Stomach pain
  • Headache
  • Heartburn Flatulence
  • Decreased appetite
  • Runny Nose

When not to use?

Contraindications of Celecoxib

Allergy

Patients with known allergy to Celecoxib or other non-steroidal anti-inflammatory (NSAID) drugs should avoid this medicine.

Asthma

Should not be given to patients with a history of NSAID-induced asthma, rhinitis and urticaria.

Coronary Artery Bypass Surgery -CABG

Not recommended in individuals with recent heart surgery


What special precautions should I follow?

Before taking Celecoxib :

Tell your doctor or pharmacist if you are allergic to it or other NSAIDs such as ibuprofen.

Tell your doctor regarding your medical history if any such as..

  • Asthma
  • Liver Disease
  • Stomach problems
  • Heart Disease
  • High BP
  • Stroke
  • Anemia

Celecoxib may cause stomach bleeding. Daily use of alcohol and tobacco combined with this drug may increase the risk for stomach bleeding.

Tell doctor if you are pregnant or if you plan to become pregnant.

This drug passes into breast milk. So avoid if you are breast feeding women.


Dosage and Administration of Celecoxib.

The Dosage will depend on:

  • Age ( Child / Adult / Infant etc)
  • The condition is being treated
  • How severe your medical condition is
  • Any other medical conditions if patient have
  • How your body reacts to the primary dose

For Osteoarthritis

Adult: 200 mg taken once per day, or 100 mg taken twice per day in interval doses.

Child: Not recommended

For Rheumatoid arthritis

Adult: 100–200 mg taken twice per day

Child (2 -17 yrs): 50 mg taken twice per day and 100 mg for those whose weight is above 25 kg

Child (0-1 yrs): Not recommended

For ankylosing spondylitis

Adult: 100–200 mg taken twice per day , If this medicine isn’t working after 6 weeks, your doctor may try 400 mg per day in single or divided doses.

Child: Not recommended

For short-term pain

Adult: 400 mg for the first dose followed by a 200-mg dose about 8–12 hours later if required. On following days, the dosage is 200 mg taken twice per day as needed.

Child: Not recommended

For menstrual cramps

Adult: 400 mg for the first dose followed by a 200-mg dose about 8–12 hours later if required. On following days, the dosage is 200 mg taken twice per day as needed.

Child: Not applicable

People with liver disease

If person have moderate liver disease, his daily dose may be reduced by half. If he has severe liver disease, he shouldn’t take this medication.

Missed Dose

The missed dose should be taken as soon as you get remember. However, the missed dose should be avoided if it is almost the time for the next dose.

Overdose

Seek emergency medical help or contact the doctor in case of overdose symptoms seen such as trouble breathing, drowsiness, loss of consciousness, vomiting and swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, lower legs


Interaction of Celecoxib

Drug/Food/Alcohol interactions may change “how your medications work” or “increase the risk for serious side / Adverse effects”. 

This medicine may interact differently for person to person and condition to condition.

You should ask for all the possible interactions with doctor before starting any medicine.

Interaction with Alcohol

Interaction of Celecoxib with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

  • Corticosteroids : MODERATE
  • Adefovir : SEVERE
  • Antihypertensives : MODERATE

Other Drug Interactions are :

  • Blood thinner, anticoagulant like Warfarin may increase the risk of bleeding
  • Mental health drug may increase the lithium toxicity with celecoxib.
  • also interacts with Blood pressure drugs, diuretics, ACE Inhibitors etc.

Disease interactions

Asthma : SEVERE

This medicine should not be taken if you have NSAID-sensitive asthma. Any such history should be reported to the doctor so that appropriate substitution can be given.

Fluid Retention and edema : SEVERE

This drug should be taken only after consulting a doctor. Monitoring of blood pressure (BP) and heart conditions is necessary on a regular basis during the course of therapy.

Food interactions 

Not reported but still it depends on person to person, so consult your doctor for more information


Celecoxib During Pregnancy

Research in animals has shown adverse effects to the fetus when the mother takes this drug hence This drug is not recommended for use in pregnant women.

Tell your doctor if you’re pregnant woman or plan to become pregnant. This drug should be used during pregnancy only if the potential benefit overcomes the potential risk to the fetus.


Celecoxib during Breast-feeding

This drug is known to be excreted in breast milk means it is shown that this medicine pass through breast milk. It is recommended in breastfeeding women only if in necessary situation.


Celecoxib For older above 65 yrs and Children

This medicine has been studied in a small number of people older than 65 years. If someone is 65 years or older, he/she may have increased risk of stomach problems and kidney failure.


General warnings

Effect on heart

It can cause adverse effects on the heart, especially after a prolonged duration of use. It may increase the risk of diseases like stroke and heart attack which may be fatal.

Impaired liver function

This medicine should be used with caution in paeople with liver injury. In patients with moderate liver injury, the dose should be reduced to 50%. This medicine is not recommended in people with severe liver disease.

Gastro-intestinal (GI) bleeding

This drug may cause severe bleeding when taken for a long time. Elderly population with a history of GI diseases are at a higher risk. Any sign of blood in stools and vomiting should be informed to the doctor.

Impaired kidney function

This medicine is known to cause severe kidney injury. Close monitoring of kidney function is required.


How Celecoxib works?

Celecoxib is belongs to a drug class called non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).


Expert Advice for Celecoxib

  • It can be given with or without food.
  • Celecoxib may cause certain stomach problems as compared with other NSAIDs like Ibuprofen or Naproxen.
  • It can also affect kidneys or cause permanent kidney damage if taken for a prolong duration.
  • It can raise your risk of blood clots, heart attack, and a stroke.
  • Report your doctor if you have ever been diagnosed with kidney or liver problems.
  • Inform your doctor if you are pregnant or planning to conceive or breastfeeding women.

Other Important Details 

Onset of action (duration of time it takes for a drug’s to come in effects)

The effect of this medicine can be observed in 2 to 3 hours after administration.

Duration of effect

The effect of this medicine lasts for an average 8 – 12 Hours.

Is it habit forming medicine?

No habit forming occurrence has been reported.

storage and disposal

Store it at room temperature and away from excess heat and moisture and importantly keep out of reach of children.


Commonly Asked Questions / FAQs

Is Celecoxib drug banned in India?

No. Celecoxib is not banned in India. It is legally available via prescription

Is Celecoxib drug gluten free?

Yes. it is gluten free. However, please refer to package insert of the prescribed brand before use

Is Celecoxib the same as Celebrex medicine?

Yes. Celebrex is famous the brand names of Celecoxib available in the market

Is Celecoxib safe?

Yes. Celecoxib is relatively safe if used as prescribed. In case of any side-effects, consult your doctor

Is Celecoxib a narcotic or addictive medicine?

No. Celecoxib is not a narcotic or addictive medicine

Does It cause drowsiness, weight gain or constipation?

Yes, Celecoxib may cause drowsiness, weight gain and constipation.

Does this medicine contain aspirin, codeine or sulfa?

No. Celecoxib is by itself is a type of medicinal compound. It does not contain any aspirin, codeine or sulfa

How does Celecoxib medicine work?

Celecoxib works by inhibiting the formation of chemicals messenger called prostaglandins in the body that cause pain and inflammation, thereby reducing the pain and swelling symptoms.
This information is to supplement, not substitute to the judgment of healthcare professionals. A healthcare professional should be consulted before taking any medicine, changing any diet or commencing or discontinuing any course of treatment.

Is this helpful to you?

I got needed information
Best article on this topic ever
Really Helpful

Overall Score

How this article helpful to you? you can comment below for any kind of query though we have covered almost all points for Celecoxib Medicine.

User Rating: 4.6 ( 3 votes)
Tags
Show More

Leave a Reply

Back to top button
Close