NSAIDs - Nonsteroidal anti-inflammatory drugs

Aceclofenac – uses, side effects, dosage and pregnancy effects

Uses, dosage, Side effects, interaction, precaution, warning for pregnancy & Breast feeding for Aceclofenac

Aceclofenac tablets for pain and inflammation

Aceclofenac is used for pain relief. It relieves pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.


Aceclofenac Classification and General Details.

  • Category : NSAIDs : Nonsteroidal anti-inflammatory agents
  • Schedule : OTC
  • Prescription : Not Required
  • Legal Status : Approved
  • Available as : Tablets

Description of Aceclofenac

Aceclofenac is used to relieve pain in the conditions like Osteoarthritis, Rheumatoid Arthritis, and Ankylosing Spondylitis.

Do not take this medicine if you have any bleeding disorder, asthma or have a known allergy.

Aceclofenac is a nonsteroidal anti-inflammatory drug prescribed to patients suffering from pain due to rheumatoid arthritis, osteoarthritis and ankylosing spondylitis.

It is also used for other conditions such as fever, head ache, dental pain, post – surgical and gynaecological pain.


Uses of Aceclofenac

Why Aceclofenac is prescribed for?

Rheumatoid Arthritis

Aceclofenac is used to treat symptoms like swelling, pain, and stiffness of joints associated with Rheumatoid Arthritis.

Osteoarthritis

Aceclofenac is used to treat symptoms like tender and painful joints associated with Osteoarthritis.

Ankylosing Spondylitis

Aceclofenac is used to treat symptoms like stiffness and pain associated with Ankylosing Spondylitis.


How to use Aceclofenac?

Before you start the treatment, read the manufacturer’s printed information leaflet from inside the pack. It will give you more information about aceclofenac, and it will also provide you with a full list of the side-effects which you could experience from taking it.

Take aceclofenac exactly as your doctor tells you to. The usual dose is one 100 mg tablet twice daily, taken preferably morning and evening.

Take aceclofenac with food; during a mealtime is ideal. This will help to protect your stomach from side-effects such as indigestion and stomach irritation.

Swallow the tablet with a drink of water. Do not chew or crush the tablets.

If you forget to take a dose, take it as soon as you remember (unless it is nearly time for your next dose, in which case take the next dose when it is due and leave out the forgotten dose). Do not take two doses together to make up for a missed dose.


Side effects / Adverse Effects

what are the Major & minor side effects for Aceclofenac?

  • Abdominal pain
  • Constipation
  • Diarrhea
  • Nausea and vomiting
  • Skin rash
  • Vomiting
  • Stomach Pain
  • Indigestion
  • Heartburn
  • Loss of appetite
  • Vertigo
  • Red itchy rashes on skin
  • Liver toxicity
  • Discomfort in upper abdomen
  • Ulcers’ in the mouth

Important: if you experience any of the following less common but possibly serious symptoms, stop taking aceclofenac and contact your doctor for advice straightaway:

  • If you have any breathing difficulties such as wheeze or breathlessness.
  • If you have any signs of an allergic reaction such as swelling around your mouth or face, or a severe itchy skin rash.
  • If you pass blood or black stools, bring up blood, or have severe tummy (abdominal) pains.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.


When not to use?

Contraindications of Aceclofenac

Allergy : Avoid if you have a known allergy to Aceclofenac or other NSAIDs.

Asthma : Aceclofenac is not recommended if you are diagnosed with asthma.

Bleeding : Aceclofenac is not recommended if you are suffering from any bleeding disorder. It could cause severe swelling and bleeding in the stomach, colon, and anus.


What special precautions should I follow?

Before taking Aceclofenac :

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking aceclofenac, it is important that your doctor knows:

If you have ever had an allergic reaction to any other NSAID (such as aspirin, naproxen, diclofenac, and indometacin), or to any other medicine.

If you have ever had a problem with stomach or duodenal bleeding, such as if you have had an ulcer.

If you have asthma or any other allergic disorder.

If you have a heart condition, or a problem with your blood vessels or circulation.

If you are pregnant, trying for a baby, or breast-feeding.

If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work.

If you have high blood pressure.

If you have ever had blood clotting problems.

If you have an inflammatory bowel disorder such as Crohn’s disease or ulcerative colitis.

If you have a connective tissue disorder such as systemic lupus erythematosus. This is an inflammatory condition which is also called lupus or SLE.

If you have a rare inherited blood disorder known as porphyria.

If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.


Dosage and Administration of Aceclofenac

The drug dosage and form are decided by the physician based upon:

  • Age and body weight of the patient
  • Health status/medical condition of the patient
  • Disease severity
  • Reaction to the first dose
  • History of allergy/drug reactions

The typical adult dose is 100mg twice daily. One 100mg tablet should be taken in the morning and one in the evening (1 tablet every 12 hours). Aceclofenac Tablets are not recommended for use in children under the age of 18.

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

Overdose

A doctor should be contacted immediately if an overdose of Aceclofenac is suspected. Signs and symptoms of overdose include rashes on the skin, confusion, pain in the chest, blurred vision etc. Immediate medical attention is needed if an overdose is confirmed.


Interaction of Aceclofenac

Drug/Food interactions may change how your medications work or increase your risk for serious side effects. 

Aceclofenac may interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol : MODERATE

Drinking alcohol with this medicine substantially increases the risks of stomach bleeding.

This medicine should not be consumed with alcohol. Symptoms of stomach bleeding (such as the presence of dried and coffee colored blood in cough or stools) should be reported to the doctor immediately.

Interaction with Medicine

  • Lithium : SEVERE
  • Digoxin : SEVERE
  • Corticosteroids : MODERATE
  • Antihypertensives : SEVERE

Interaction have been also noticed with the following drugs:

  1. Warfarin
  2. Steroids
  3. Diuretics (drugs used to increase the rate of urine excretion)
  4. Drugs used to lower blood sugar level in diabetes patients
  5. Methotrexate (used to treat cancer, arthritis)
  6. Ciclosporin and Tacrolimus (drugs used to suppress the immune system)
  7. Antibiotics such as quinoline
  8. Zidovudine (drug used to treat HIV)
  9. Other non-steroidal anti-inflammatory agents like aspirin, ibuprofen
  10. Medicines used to treat high blood pressure (antihypertensives)
  11. Digoxin (used to treat heart failure and irregular heartbeats)

Disease interactions

Asthma : SEVERE

Aceclofenac should not be taken if you have NSAID-sensitive asthma. Any such history should be reported to the doctor so that appropriate substitution can be done.

Gastro-Intestinal toxicity : SEVERE

Aceclofenac and other NSAIDs should be taken after consulting a doctor especially if the intended duration is longer than a month. Any symptom indicating ulceration and bleeding like chronic indigestion, appearance of coffee colored dry blood in stools or vomiting of blood should be reported immediately.

Impaired kidney function : SEVERE

Aceclofenac should be taken after consulting a doctor if you suffering from a kidney disease. Suitable adjustment in dosage and monitoring of kidney functions is required in such situations.

Food interactions 

Not reported but still it depends on person to person, so consult your doctor for more information


Aceclofenac During Pregnancy & Breast feeding

This medicine is not recommended for pregnant women and also not recommended for breastfeeding women. significance effects found in pregnancy and breast feeding


General warnings

Gastro-intestinal bleeding

Aceclofenac can cause severe bleeding when taken for a long time. Elderly population with the history of the gastrointestinal disease are at higher risk.

Heart surgery

Aceclofenac should not be taken to relieve pain before or after undergoing a CABG (coronary artery bypass surgery).

Asthma

Aceclofenac is not recommended if you have asthma or family history of asthma.

Impaired kidney function

Aceclofenac is not recommended if you are suffering from impaired kidney function.

Impaired liver function

Use with caution with an initial dose of 100 mg once a day in the mild liver failure. Contraindicated in severe liver failure.

Reported Allergic Reactions

Possible allergic reactions reported are excessive pain, wheezing, difficulty in breathing, vomiting, rashes and itching on skin, painful, tender wounds on lips and mouth.

Effects on organs

In patients suffering from liver diseases, dose of Aceclofenac should be reduced to an initial daily dose of 100 mg. If you suffer from a kidney disease, Aceclofenac should be taken only after consulting a doctor. Suitable adjustment of dose and monitoring of kidney functions is mandatory in such cases.


How Aceclofenac works?

Aceclofenac is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).


Expert Advice for Aceclofenac

You have been prescribed Aceclofenac to relieve pain and inflammation.

Take it with food or milk to prevent upset stomach.

Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.

It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration.

Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems.

Inform your doctor if you have a history of heart disease or stroke.

Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment.


Other Important Details

Onset of action

The peak effect of this medicine can be observed in 1.5 to 3 hours after oral administration.

Duration of effect

This medicine is excreted in urine and the effect lasts for a duration of 12 to 16 hours.

Is it habit forming?

No habit forming tendency has been reported.

storage and disposal

Always Store Aceclofenac tablets below 25°C and away from direct light and heat.


Commonly Asked Questions / FAQs

Is aceclofenac safe?

Aceclofenac (also available as Hifenac, Zerodol) is safe at the prescribed dose by the doctor. Patients should follow the advice of the doctor regarding its use

Is aceclofenac a painkiller/ antipyretic/ antibiotic?

Aceclofenac is a pain relieving medication and not an antibiotic. It may reduce fever; however consult your doctor regarding its use

Can I have Aceclofenac with alcohol?

No. Immediately inform your physician if you notice signs of bleeding in stomach (dried and coffee coloured blood in cough or stools).

Is aceclofenac better than diclofenac?

Aceclofenac is structurally related and metabolised to diclofenac. Both are equally effective and safe in relieving pain. Patients should follow the advice of the doctor regarding its use

Is Aceclofenac Addictive?

No

Is aceclofenac paracetamol/ aspirin?

No. Aceclofenac is not paracetamol or aspirin.

Any particular food item to be avoided?

No

Can I have Aceclofenac When Pregnant?

Always inform your doctor if you are pregnant or plan to become pregnant. Aceclofenac is not recommended for pregnant women.

Can I have Aceclofenac when feeding a baby?

Always inform your doctor if you are breast-feeding your child. Aceclofenac is not recommended for lactating women.

Can I drive after taking Aceclofenac?

You should avoid driving if you feel dizzy, drowsy or sleepy after taking Aceclofenac Tablets.

What happens if I overdose on Aceclofenac?

If you have taken an over-dose, it is advisable to contact your consulting physician immediately.

What happens if I eat expired Aceclofenac?

It is very unlikely for a single dose of expired Aceclofenac to produce an adverse event. However, please consult your physician if you feel unwell or sick after consuming an expired medicine. An expired drug might not be as potent in treating your condition. It is advisable to refrain from using expired drug.

What happens if I miss a dose of Aceclofenac?

The medicine may not work well if you miss a dose because for effective working of the drug, a certain amount of drug must be present in your body at all times. Always consume the missed dose as soon as you remember it. But, if it’s already time to take the second dose after that – do not take double dose.
This information is to supplement, not substitute to the judgment of healthcare professionals. A healthcare professional should be consulted before taking any medicine, changing any diet or commencing or discontinuing any course of treatment.

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